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Year : 2020  |  Volume : 33  |  Issue : 6  |  Page : 344-346

Overlapping polyclonal lymphoproliferative disorders

1 Division of Internal Medicine, AOU Maggiore della Carità, Novara, Italy
2 IRCAD, Interdisciplinary Research Center of Autoimmune Diseases, Novara, Italy
3 Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy
4 Department of Pathology, Università del Piemonte Orientale UPO, Novara, Italy

Correspondence Address:
Francesco Gavelli
Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-258X.321144

Multicentric Castleman disease (MCD) is a rare clinical entity characterized by a polyclonal lymphoid proliferation, leading to generalized lymphadenopathy, organomegaly and systemic symptoms. It has been reported in association with either other monoclonal or polyclonal lymphoid disorders, such as POEMS syndrome and immunoglobulin (Ig)G4-related disease. We present a patient showing a variant of MCD, sharing common features with POEMS syndrome and associated with the proliferation of IgG4-producing plasma cells.

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